Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Author:

Mann Elizabeth R.12ORCID,Menon Madhvi1,Knight Sean Blandin13,Konkel Joanne E.1,Jagger Christopher1ORCID,Shaw Tovah N.1ORCID,Krishnan Siddharth1ORCID,Rattray Magnus4ORCID,Ustianowski Andrew5,Bakerly Nawar Diar3ORCID,Dark Paul67,Lord Graham M.1,Simpson Angela6,Felton Timothy6ORCID,Ho Ling-Pei8,Feldmann Marc9,Grainger John R.1ORCID,Hussell Tracy1ORCID, ,

Affiliation:

1. Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester M13 9PL, UK.

2. Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 5th Floor St. Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

3. Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.

4. Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

5. Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK.

6. Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, UK.

7. Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.

8. MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

9. Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford OX3 7LD, UK.

Abstract

Longitudinal analysis of the immune response in patients with COVID-19 identifies a myeloid signature associated with severe disease.

Funder

Wellcome

Biotechnology and Biological Sciences Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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