SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

Author:

Altmann Daniel M.1ORCID,Boyton Rosemary J.23

Affiliation:

1. Department of Immunology and Inflammation, Imperial College, London W12 0NN, UK.

2. Department of Infectious Disease, Imperial College, London W12 0NN, UK.

3. Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK.

Abstract

Answers are starting to emerge about target antigens and cytokine profiles of CD4 and CD8 subsets responding to SARS-CoV-2.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference19 articles.

1. SARS-CoV-2 infection protects against rechallenge in rhesus macaques;Chandrashekar A.;Science,2020

2. A. E. Oja A. Saris C. A. Ghandour N. A. M. Kragten B. M. Hogema E. J. Nossent L. M. A. Heunks S. Cuvalay E. Slot F. H. Swaneveld H. Vrielink T. Rispens E. van der Schoot R. A. W. van Lier A. Ten Brinke P. Hombrink Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19. bioRxiv 2020.06.18.159202 [ Preprint ]. 18 June 2020. https://doi.org/10.1101/2020.06.18.159202.

3. T. Sekine A. Perez-Potti O. Rivera-Ballesteros K. Strålin J.-B. Gorin A. Olsson S. Llewellyn-Lacey H. Kamal G. Bogdanovic S. Muschiol D. J. Wullimann T. Kammann J. Emgård T. Parrot E. Folkesson O. Rooyackers L. I. Eriksson A. Sönnerborg T. Allander J. Albert M. Nielsen J. Klingström S. Gredmark-Russ N. K. Björkström J. K. Sandberg D. A. Price H.-G. Ljunggren S. Aleman M. Buggert Karolinska COVID-19 Study Group Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19. bioRxiv 2020.06.29.174888 [ Preprint ]. 29 June 2020. https://doi.org/10.1101/2020.06.29.174888.

4. F. Gallais A. Velay M.-J. Wendling C. Nazon M. Partisani J. Sibilia S. Candon S. Fafi-Kremer Intrafamilial exposure to SARS-CoV-2 induces cellular immune response without seroconversion. medRxiv 2020.06.21.20132449 [ Preprint ]. 22 June 2020. https://doi.org/10.1101/2020.06.21.20132449.

5. Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

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