DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs

Author:

Wang Shao-bin12ORCID,Narendran Siddharth123ORCID,Hirahara Shuichiro12,Varshney Akhil12,Pereira Felipe124ORCID,Apicella Ivana12,Ambati Meenakshi125,Ambati Vidya L.5,Yerramothu Praveen12,Ambati Kameshwari12,Nagasaka Yosuke12,Argyle Dionne12ORCID,Huang Peirong12ORCID,Baker Kirstie L.6ORCID,Marion Kenneth M.6ORCID,Gupta Kartik7ORCID,Liu Bo7,Hinton David R.8,Canna Scott W.9ORCID,Sallam Tamer1011ORCID,Sadda Srinivas R.612,Kerur Nagaraj121314,Gelfand Bradley D.1215ORCID,Ambati Jayakrishna121316ORCID

Affiliation:

1. Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.

2. Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.

3. Aravind Eye Care System, Madurai, India.

4. Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.

5. Center for Digital Image Evaluation, Charlottesville, VA, USA.

6. Doheny Eye Institute, Los Angeles, Los Angeles, CA, USA.

7. Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.

8. Departments of Pathology and Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

9. Pediatric Rheumatology & RK Mellon Institute for Pediatric Research, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

10. Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

11. Molecular Biology Institute, Center for Health Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

12. Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

13. Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA.

14. Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.

15. Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA, USA.

16. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Abstract

DDX17 senses retrotransposon RNA and activates a noncanonical NLRC4 inflammasome.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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