Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria-Reference-Cited by-同舟云学术

Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria

Published:2023-02-03 Issue:80 Volume:8 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Philippot Quentin¹²^ORCID,Ogishi Masato³^ORCID,Bohlen Jonathan¹²^ORCID,Puchan Julia⁴^ORCID,Arias Andrés Augusto³⁵⁶^ORCID,Nguyen Tina⁷⁸^ORCID,Martin-Fernandez Marta⁹¹⁰¹¹¹²¹³^ORCID,Conil Clement¹²,Rinchai Darawan³^ORCID,Momenilandi Mana¹²^ORCID,Mahdaviani Seyed Alireza¹⁴^ORCID,Keramatipour Mohammad¹⁵^ORCID,Rosain Jérémie¹²^ORCID,Yang Rui³^ORCID,Khan Taushif¹⁶^ORCID,Neehus Anna-Lena¹²^ORCID,Materna Marie¹²^ORCID,Han Ji Eun³^ORCID,Peel Jessica³,Mele Federico¹⁷^ORCID,Weisshaar Marc⁴^ORCID,Jovic Sandra¹⁷^ORCID,Bastard Paul¹²³¹⁸^ORCID,Lévy Romain¹²¹⁸^ORCID,Le Voyer Tom¹²^ORCID,Zhang Peng³^ORCID,Maglorius Renkilaraj Majistor Raj Luxman¹²^ORCID,Arango-Franco Carlos A.¹⁵^ORCID,Pelham Simon³^ORCID,Seeleuthner Yoann¹²,Pochon Mathieu¹²,Ata Manar Mahmoud Ahmad¹⁶^ORCID,Al Ali Fatima¹⁶^ORCID,Migaud Mélanie¹²^ORCID,Soudée Camille¹²,Kochetkov Tatiana³,Molitor Anne¹⁹²⁰^ORCID,Carapito Raphael¹⁹²⁰²¹^ORCID,Bahram Seiamak¹⁹²⁰²¹^ORCID,Boisson Bertrand¹²³^ORCID,Fieschi Claire²²^ORCID,Mansouri Davood¹⁴²³,Marr Nico¹⁶²⁴²⁵^ORCID,Okada Satoshi²⁶^ORCID,Shahrooei Mohammad²⁷²⁸,Parvaneh Nima²⁹^ORCID,Chavoshzadeh Zahra³⁰^ORCID,Cobat Aurélie¹²³^ORCID,Bogunovic Dusan¹⁰¹¹¹²¹³¹⁴^ORCID,Abel Laurent¹²³^ORCID,Tangye Stuart G.⁸⁹^ORCID,Ma Cindy S.⁸⁹^ORCID,Béziat Vivien¹²³^ORCID,Sallusto Federica⁴¹⁷^ORCID,Boisson-Dupuis Stéphanie¹²³^ORCID,Bustamante Jacinta¹²³³¹^ORCID,Casanova Jean-Laurent¹²³³²³³^ORCID,Puel Anne¹²³^ORCID

Affiliation:

1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.

2. University Paris Cité, Imagine Institute, Paris, France.

3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.

4. Institute of Microbiology, ETH Zürich, Zürich, Switzerland.

5. Primary Immunodeficiencies Group, University of Antioquia (UdeA), Medellin, Colombia.

6. School of Microbiology, University of Antioquia (UdeA), Medellin, Colombia.

7. Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

8. School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.

9. Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

10. Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

11. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

12. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

13. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

14. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

15. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

16. Department of Human Immunology, Sidra Medicine, Doha, Qatar.

17. Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.

18. Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.

19. Molecular Immuno-Rheumatology Laboratory, INSERM UMR_S1109, GENOMAX Platform, Faculty of Medicine, OMICARE University Hospital Federation, Immunology and Hematology Research Center, Research Center in Biomedicine of Strasbourg (CRBS), Federation of Translational Medicine of Strasbourg (FMTS), University of Strasbourg, Strasbourg, France.

20. Interdisciplinary Thematic Institute (ITI) of Precision Medicine of Strasbourg, Strasbourg, France.

21. Immunology Laboratory, Biology Technical Platform, Biology Pole, New Civil Hospital, Strasbourg, France.

22. Clinical Immunology Department, Saint Louis Hospital, Paris, France.

23. Clinical Tuberculosis and Epidemiology Research Centre, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

24. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.

25. Institute of Translational Immunology, Brandenburg Medical School, Brandenburg an der Havel, Germany.

26. Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima-Shi, Hiroshima, Japan.

27. Clinical and Diagnostic Immunology, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Belgium.

28. Dr. Shahrooei Lab, 22 Bahman St., Ashrafi Esfahni Blvd, Teheran, Iran.

29. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Teheran, Iran.

30. Pediatric Infections Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

31. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France.

32. Howard Hughes Medical Institute, New York, NY, USA.

33. Department of Pediatrics, Necker Hospital for Sick Children, Paris, France.

Abstract

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less commonly, chronic mucocutaneous candidiasis (CMC) due to impaired IL-17A/F production. We report six patients from four kindreds with AR IL-23R deficiency. These patients are homozygous for one of four different loss-of-function IL23R variants. All six patients have a history of MSMD, but only two suffered from CMC. We show that IL-23 induces IL-17A only in MAIT cells, possibly contributing to the incomplete penetrance of CMC in patients unresponsive to IL-23. By contrast, IL-23 is required for both baseline and Mycobacterium -inducible IFN-γ immunity in both Vδ2 + γδ T and MAIT cells, probably contributing to the higher penetrance of MSMD in these patients. Human IL-23 appears to contribute to IL-17A/F–dependent immunity to Candida in a single lymphocyte subset but is required for IFN-γ–dependent immunity to Mycobacterium in at least two lymphocyte subsets.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Link

https://www.science.org/doi/pdf/10.1126/sciimmunol.abq5204

Reference94 articles.

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