Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

Author:

Iyer Anita S.12ORCID,Jones Forrest K.3,Nodoushani Ariana1ORCID,Kelly Meagan1,Becker Margaret1ORCID,Slater Damien1ORCID,Mills Rachel1ORCID,Teng Erica1ORCID,Kamruzzaman Mohammad1ORCID,Garcia-Beltran Wilfredo F.4,Astudillo Michael4,Yang Diane4ORCID,Miller Tyler E.4ORCID,Oliver Elizabeth1ORCID,Fischinger Stephanie5ORCID,Atyeo Caroline5ORCID,Iafrate A. John4ORCID,Calderwood Stephen B.126ORCID,Lauer Stephen A.3ORCID,Yu Jingyou7ORCID,Li Zhenfeng7,Feldman Jared5ORCID,Hauser Blake M.5ORCID,Caradonna Timothy M.5ORCID,Branda John A.4,Turbett Sarah E.124ORCID,LaRocque Regina C.12ORCID,Mellon Guillaume1ORCID,Barouch Dan H.57ORCID,Schmidt Aaron G.56ORCID,Azman Andrew S.3ORCID,Alter Galit5ORCID,Ryan Edward T128,Harris Jason B.19ORCID,Charles Richelle C.12

Affiliation:

1. Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.

2. Department of Medicine, Harvard Medical School, Boston, MA, USA.

3. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

4. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

5. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

6. Department of Microbiology, Harvard Medical School, Boston, MA, USA.

7. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

8. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

9. Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Abstract

IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.

Funder

National Institutes of Health

Centers for Disease Control and Prevention

MassCPR

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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