Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin-Reference-Cited by-同舟云学术

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin

Published:2021-10-29 Issue:64 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Takahashi H.¹^ORCID,Nomura H.¹,Iriki H.¹^ORCID,Kubo A.²^ORCID,Isami K.¹^ORCID,Mikami Y.³^ORCID,Mukai M.¹^ORCID,Sasaki T.⁴^ORCID,Yamagami J.¹,Kudoh J.⁵,Ito H.¹,Kamata A.¹,Kurebayashi Y.⁶^ORCID,Yoshida H.⁷^ORCID,Yoshimura A.⁸,Sun H. W.⁹^ORCID,Suematsu M.²^ORCID,O’Shea J. J.³^ORCID,Kanno Y.³,Amagai M.¹¹⁰

Affiliation:

1. Department of Dermatology, Keio University School of Medicine, Tokyo 160-8582, Japan.

2. Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan.

3. Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.

5. Laboratory of Gene Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.

6. Department of Pathology, Keio University School of Medicine, Tokyo 160-8582, Japan.

7. Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849-8501, Japan.

8. Department of Immunology and Microbiology, Keio University School of Medicine, Tokyo 160-8582, Japan.

9. Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

10. Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan.

Abstract

CD4 + T cells limit pathogenic bystander T cell expansion by suppressing cholesterol biosynthesis via secreted 25-hydroxycholesterol.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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