The lung is a host defense niche for immediate neutrophil-mediated vascular protection

Author:

Yipp Bryan G.12ORCID,Kim Jung Hwan12ORCID,Lima Ronald23ORCID,Zbytnuik Lori D.23,Petri Bjӧrn245ORCID,Swanlund Nick23ORCID,Ho May25,Szeto Vivian G.23ORCID,Tak Tamar67,Koenderman Leo67ORCID,Pickkers Peter8ORCID,Tool Anton T. J.9ORCID,Kuijpers Taco W.9ORCID,van den Berg Timo K.910ORCID,Looney Mark R.11,Krummel Matthew F.12ORCID,Kubes Paul12345ORCID

Affiliation:

1. Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

2. Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

3. Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

4. Mouse Phenomics Resource Laboratory, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

5. Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

6. Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands.

7. Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

8. Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.

9. Department of Blood Cell Research, Sanquin Research, and Landsteiner Laboratory, Amsterdam, Netherlands.

10. Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, Netherlands.

11. Departments of Medicine and Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSW512, CA 94143–0511, USA.

12. Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, HSW512, San Francisco, CA 94143–0511, USA.

Abstract

Pulmonary capillaries provide a home for neutrophil surveillance to capture bloodstream bacteria.

Funder

CIHR

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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