Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

Author:

Lee Jeong Seok1ORCID,Park Seongwan2ORCID,Jeong Hye Won3ORCID,Ahn Jin Young4ORCID,Choi Seong Jin1ORCID,Lee Hoyoung1ORCID,Choi Baekgyu2ORCID,Nam Su Kyung2ORCID,Sa Moa15ORCID,Kwon Ji-Soo16ORCID,Jeong Su Jin4ORCID,Lee Heung Kyu15ORCID,Park Sung Ho7ORCID,Park Su-Hyung15ORCID,Choi Jun Yong4ORCID,Kim Sung-Han6ORCID,Jung Inkyung2ORCID,Shin Eui-Cheol15ORCID

Affiliation:

1. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

2. Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

3. Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Republic of Korea.

4. Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

5. The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea.

6. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.

7. School of Life Sciences, Ulsan National Institute of Science & Technology (UNIST), Ulsan 44919, Republic of Korea.

Abstract

Single-cell RNA sequencing of blood immune cells reveals type I interferon–associated hyper-inflammation in severe COVID-19.

Funder

Samsung Science and Technology Foundation

SUHF Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference37 articles.

1. A new coronavirus associated with human respiratory disease in China

2. A Novel Coronavirus from Patients with Pneumonia in China, 2019

3. World Health Organization Coronavirus disease 2019 (COVID-19) Situation Report−134. (2 June 2020); www.who.int/docs/default-source/coronaviruse/situation-reports/20200602-covid-19-sitrep-134.pdf?sfvrsn=cc95e5d5_2.

4. Clinical Characteristics of Coronavirus Disease 2019 in China

5. Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China

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