Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage-Reference-Cited by-同舟云学术

Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

Published:2021-02-12 Issue:56 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Askenase Michael H.¹²^ORCID,Goods Brittany A.³⁴⁵⁶,Beatty Hannah E.¹²^ORCID,Steinschneider Arthur F.¹²,Velazquez Sofia E.¹²^ORCID,Osherov Artem¹²^ORCID,Landreneau Margaret J.¹²^ORCID,Carroll Shaina L.³⁴⁵⁶^ORCID,Tran Tho B.¹²^ORCID,Avram Victor S.¹²^ORCID,Drake Riley S.³⁴⁵⁶^ORCID,Gatter G. James³⁴⁵⁶^ORCID,Massey Jordan A.¹²^ORCID,Karuppagounder Saravanan S.⁷⁸,Ratan Rajiv R.⁷⁸,Matouk Charles C.⁹,Sheth Kevin N.⁹^ORCID,Ziai Wendy C.¹⁰¹¹,Parry-Jones Adrian R.¹²¹³,Awad Issam A.¹⁴,Zuccarello Mario¹⁵^ORCID,Thompson Richard E.¹⁰¹⁶,Dawson Jesse¹⁷^ORCID,Hanley Daniel F.¹⁰^ORCID,Love J. Christopher⁴⁵¹⁸^ORCID,Shalek Alex K.³⁴⁵⁶^ORCID,Sansing Lauren H.¹²¹⁹^ORCID,Barrer Steven J.,MacKenzie Larami,Jonczak Karin,Bussinger Patricia,Nakaji Peter,Wright Shawn E.,Honea Norissa,Zomorodi Ali,James Michael,Yeh Erlinda,Galicich Walter,Bergman Thomas,France Kathryn,Leiphart James,Ramesh Swathi,Brennan Tricia,Huang Judy,Ziai Wendy,White Mirinda Anderson,Camarata Paul,Abraham Michael,Gorup Jason,Reimer Ronald,Freeman W. David,Williams Cristin,Edwards Emily,Pollack Ania,Terry John,Shoen Angela,Jahromi Babak S.,Maas Matthew B.,Yip Byron,Amidei Christina,Muñoz Lorenzo,Lopez George,Holtz Rebecca,Gupta Gaurav,Rybinnik Igor,Moccio Michelle,Lovick Darren,Brion Bridget,Titus Kelsey,Jallo Jack,Rincon Fred,Pigott Kara,Boyden Laura,Dougherty Jaime,Harrigan Mark,Miller David,Nelson Lisa,Thompson Gregory,Rajajee Ventatakrishna,Pandey Aditya,Ball Ron,Carlson Andrew,Tran Huy,Alchbli Amal,James Robert F.,Jerde Ann,Taussky Philipp,Ansari Safdar,Neate Crystal,Martinez Julie Kay,Letsinger Joshua,Fagatele Lilly,Eaquinto Carol,Matouk Charles,Sheth Kevin,Sansing Lauren,Ryall Linda,Kunze Kimberly,Mampre David,Jasak Sara,Abdul-Rahim Azmil,Abou-Hamden Amal,Abraham Michael,Ahmed Azam,Alba Carlos Alarcon,Aldrich E. Francois,Ali Hasan,Altschul David,Amin-Hanjani Sepideh,Anderson Craig S.,Anderson Doug,Ansari Safdar,Antezana David,Ardelt Agnieszka,Arikan Fuat,Awad Radhika,Baguena Marcelino,Baker Alexandra,Barrer Steven J.,Barzo Pal,Becker Kyra J.,Bergman Thomas,Betz Joshua,Bistran-Hall Amanda,Boström Azize,Braun Jamie,Brindley Peter,Broaddus William C.,Brown Robert,Buki Andras,Bulters Diederik,Camarata Paul,Cao Bing,Cao Ying,Carhuapoma J R,Carlson Andrew,Caron Jean-Louis,Carrion-Penagos Julian,Chalela Julio,Chang Tiffany,Chicoine Michael,Chorro Indalecio Moran,Chowdhry Shakeel,Cobb Cully,Corral Luisa,Csiba Laszlo,Davies Jason,Dawson Jesse,Díaz Alberto Torres,Derdeyn Colin P.,Diringer Michael,Dlugash Rachel,Dodd Robert,Ecker Robert,Economas Tracey,Enriquez Pedro,Ezer Erzsebet,Fan Yuhua,Feng Hua,Franz Douglas,Freeman W. David,Fusco Matthew,Galicich Walter,Gandhi Dheeraj,Gelea Mary Leigh,Goldstein Joshua,Gonzalez Alejandro Carrasco,Grabarits Christina,Greenberg Steven,Gregson Barbara,Gress Daryl,Gu Eugene,Gupta Gaurav,Hall Christiana,Hanley Dan^ORCID,Hao Yi,Harnof Sagi,Harrigan Mark,Hernandez Fernando Muñoz,Hoesch Robert,Hoh Brian L.,Houser Jennifer,Hu Rong,Huang Judy,Huang Yi,Hussain Mohammed Akbar,Insinga Salvatore,Jadhav Ashutosh,Jaffe Jennifer,Jahromi Babak S.,Jallo Jack,James Michael,James Robert F.,Janis Scott,Jankowitz Brian,Jeon Esther,Jichici Draga,Jonczak Karin,Jonker Ben,Karlen Nicki,Kase Carlos,Keric Naureen,Kerz Thomas,Kitagawa Ryan,Knopman Jared,Koenig Carolyn,Krishnamurthy Satish,Kumar Avinash,Kureshi Inam,Laidlaw John,Lakhanpal Arun,Lane Karen,Latorre Julius Gene,LeDoux David,Lees Kennedy,Leifer Dana,Leiphart James,Lenington Sarah,Li Yunke,Lopez George,Lovick Darren,Lumenta Christianto,Luo Jinbiao,Maas Matthew B.,MacDonald Joel,MacKenzie Larami,Madan Vikram,Majkowski Ryan,Major Otto,Malhorta Rishi,Malkoff Marc,Mangat Halinder,Maswadeh Ahmed,Matouk Charles,Mayo Steven,McArthur Kate,McBee Nichol,McCaul Scott,Medow Joshua,Mendelow A. David,Mezey Geza,Mighty Janet,Miller David,Mitchell Patrick,Mohan Krishna K.,Money P Lynn,Mould W. Andrew,Muir Keith,Muñoz Lorenzo,Nakaji Peter,Nee Alex,Nekoovaght-Tak Saman,Nyquist Paul,O’Kane Roddy,Okasha Mohamed,O'Kelly Cian,Ostapkovich Noeleen,Pandey Aditya,Parry-Jones Adrian,Patel Hiren,Perla Krissia Rivera,Pollack Ania,Polster Sean,Pouratian Nader,Quinn Terry,Rajajee Ventatakrishna,Reddy Kesava,Rehman Mohammed,Reimer Ronald,Rincon Fred,Rosenblum Michael,Rybinnik Igor,Sanchez Baltasar,Sansing Lauren^ORCID,Sarabia Rosario,Schneck Michael,Schuerer Ludwig,Schul David,Schweitzer Jeffrey,Seder David B.,Seyfried Donald,Sheth Kevin^ORCID,Spiotta Alejandro,Stadnik Agnieszka,Stechison Michael,Sugar Elizabeth,Szabo Katalin,Tamayo Gonzalo,Tanczos Krisztian,Taussky Philipp,Teitelbaum Jeanne,Terry John,Testai Fernando,Thomas Kathrine,Thompson Carol B.,Thompson Gregory,Thompson Richard,Torner James C.,Tran Huy,Tucker Kristi,Ullman Natalie,Ungar Lior,Unterberg Andreas,Varelas Panos,Vargas Nataly Montano,Vatter Hartmut,Venkatasubramanian Chitra,Vermillion Krista,Vespa Paul,Vollmer Dennis,Wang Weimin,Wang Yan,Wang Ying,Wen Jiajun,Whitworth Louis Tony,Willis Byron,Wilson Alastair,Wolfe Stacey,Wrencher Myriha,Wright Shawn E.,Xu Yongge,Yanase Lisa,Yenokyan Gayane,Yi Xuxia,Yu Zhiyuan,Ziai Wendy,Zomorodi Ali,Zuccarello Mario, , , ,

Affiliation:

1. Department of Neurology, Yale School of Medicine, New Haven, CT, USA.

2. Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.

3. Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.

4. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.

5. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

6. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

7. Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY, USA.

8. Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

9. Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

10. Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.

11. Departments of Neurology, Neurosurgery, and Anesthesiology/Critical Care Medicine, Johns Hopkins, Baltimore, MD, USA.

12. Division of Cardiovascular Sciences, School of Medicine, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

13. Manchester Centre for Clinical Neurosciences, Salford Royal National Health Service Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.

14. Neurovascular Surgery Program, Section of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.

15. Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

16. Department of Biostatistics, School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

17. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

18. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.

19. Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT, USA.

Abstract

RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

National Institute of Neurological Disorders and Stroke

Alfred P. Sloan Foundation

American Heart Association

Arnold and Mabel Beckman Foundation

Searle Scholars Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference75 articles.

1. Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

2. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

3. Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

4. Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage

5. Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

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