Neutrophil cytoplasts induce T H 17 differentiation and skew inflammation toward neutrophilia in severe asthma

Author:

Krishnamoorthy Nandini1,Douda David N.1ORCID,Brüggemann Thayse R.1ORCID,Ricklefs Isabell1,Duvall Melody G.1ORCID,Abdulnour Raja-Elie E.1,Martinod Kimberly2ORCID,Tavares Luciana1,Wang Xiao3,Cernadas Manuela1ORCID,Israel Elliot1,Mauger David T.4,Bleecker Eugene R.5,Castro Mario6ORCID,Erzurum Serpil C.7,Gaston Benjamin M.8,Jarjour Nizar N.9ORCID,Wenzel Sally10ORCID,Dunican Eleanor11ORCID,Fahy John V.11ORCID,Irimia Daniel3ORCID,Wagner Denisa D.2ORCID,Levy Bruce D.1ORCID,

Affiliation:

1. Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

2. Program in Cellular and Molecular Medicine, Division of Hematology and Oncology, Boston Children’s Hospital, Boston, MA 02115, USA.

3. BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA.

4. Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, PA 17033, USA.

5. Center for Genomics and Personalized Medicine Research, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.

6. Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pediatrics, Washington University, St. Louis, MO 63110, USA.

7. Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA.

8. Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.

9. Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine, Madison, WI 53792, USA.

10. Pulmonary, Allergy, and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

11. Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Neutrophil cytoplasts promote T H 17 inflammation.

Funder

National Heart, Lung, and Blood Institute

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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