CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19

Author:

Mallajosyula Vamsee1ORCID,Ganjavi Conner2ORCID,Chakraborty Saborni3ORCID,McSween Alana M.1ORCID,Pavlovitch-Bedzyk Ana Jimena4,Wilhelmy Julie1,Nau Allison1ORCID,Manohar Monali5,Nadeau Kari C.15ORCID,Davis Mark M.167ORCID

Affiliation:

1. Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Biology, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA.

3. Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

4. Computational and Systems Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Sean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary, Allergy, Critical Care Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

6. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

T cells specific for conserved coronavirus antigens are preferentially expanded in patients with mild COVID-19.

Funder

Howard Hughes Medical Institute

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Sean N. Parker Center for Allergy and Asthma Research, Stanford University

International Team for Implantology

Sunshine Foundation

Bill and Melinda Gates Foundation to MMD

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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