High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules-Reference-Cited by-同舟云学术

High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules

Published:2019-07-05 Issue:37 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Moritz Andreas¹²^ORCID,Anjanappa Raghavendra³^ORCID,Wagner Claudia²^ORCID,Bunk Sebastian²,Hofmann Martin²^ORCID,Pszolla Gabriele²,Saikia Ankur³^ORCID,Garcia-Alai Maria⁴,Meijers Rob⁴^ORCID,Rammensee Hans-Georg¹^ORCID,Springer Sebastian³^ORCID,Maurer Dominik²^ORCID

Affiliation:

1. Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.

2. Immatics Biotechnologies GmbH, Tübingen, Germany.

3. Department of Life Sciences and Chemistry, Jacobs University, Bremen, Germany.

4. European Molecular Biology Laboratory (EMBL), Hamburg Outstation, Notkestrasse 85, D-22607 Hamburg, Germany.

Abstract

Functionally empty and peptide-receptive soluble HLA-A*02:01 enables high-throughput analysis of TCR binding to peptide-MHCs. See the related Research Article by Saini et al . in this issue.

Funder

Deutsche Forschungsgemeinschaft

iNEXT

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference41 articles.

1. Peptides Naturally Presented by MHC Class I Molecules

2. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

3. Phenotypic Analysis of Antigen-Specific T Lymphocytes

4. High-Throughput T-Cell Epitope Discovery Through MHC Peptide Exchange

5. T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization

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