IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Author:

Wang Huimeng12ORCID,Kjer-Nielsen Lars1ORCID,Shi Mai13ORCID,D’Souza Criselle14ORCID,Pediongco Troi J.1,Cao Hanwei1,Kostenko Lyudmila1,Lim Xin Yi1ORCID,Eckle Sidonia B. G.1,Meehan Bronwyn S.1ORCID,Zhu Tianyuan13,Wang Bingjie1,Zhao Zhe1ORCID,Mak Jeffrey Y. W.56ORCID,Fairlie David P.56ORCID,Teng Michele W. L.7ORCID,Rossjohn Jamie8910ORCID,Yu Di11ORCID,de St Groth Barbara Fazekas12ORCID,Lovrecz George13,Lu Louis13,McCluskey James1ORCID,Strugnell Richard A.1ORCID,Corbett Alexandra J.1ORCID,Chen Zhenjun1ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

2. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.

3. School of Medicine, Tsinghua University, Beijing, China.

4. Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia.

5. Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.

6. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.

7. QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.

8. Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.

9. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.

10. Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, CF14 4XN Wales, UK.

11. John Curtin School of Medical Research, The Australian National University, Acton, ACT 2601 Australia.

12. Discipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.

13. Biomedical Manufacturing, CSIRO, Parkville, VIC, 3052, Australia.

Abstract

ICOS- and IL-23–mediated costimulation are important for driving in vivo activation of antigen-specific MAIT cells.

Funder

Australian Research Council

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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