Recovery from the Middle East respiratory syndrome is associated with antibody and T cell responses

Author:

Zhao Jingxian12ORCID,Alshukairi Abeer N.3ORCID,Baharoon Salim A.4,Ahmed Waleed A.3,Bokhari Ahmad A.3,Nehdi Atef M.5,Layqah Laila A.5,Alghamdi Mohammed G.6,Al Gethamy Manal M.7ORCID,Dada Ashraf M.3ORCID,Khalid Imran3,Boujelal Mohamad5,Al Johani Sameera M.4,Vogel Leatrice8,Subbarao Kanta8ORCID,Mangalam Ashutosh9ORCID,Wu Chaorong10ORCID,Ten Eyck Patrick10ORCID,Perlman Stanley2ORCID,Zhao Jincun111ORCID

Affiliation:

1. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.

2. Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.

3. King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi Arabia.

4. King Saud bin Abdulaziz for Health Sciences University, Riyadh, Kingdom of Saudi Arabia.

5. King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia.

6. King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.

7. Al Nour Specialist Hospital, Makkah, Kingdom of Saudi Arabia.

8. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

9. Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.

10. Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA 52242, USA.

11. Guangzhou Eighth People’s Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China.

Abstract

MERS-CoV T cell responses can be detected in MERS survivors in the absence of detectable virus-specific antibody.

Funder

National Institutes of Health

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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