Affiliation:
1. Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Abstract
The ability of the adaptive immune system to form memory is key to providing protection against secondary infections. Resident memory T cells (TRM) are specialized T cell populations that reside within tissue sites where they await reencounter with their cognate antigen. TRMare distinct from circulating memory cells, including central and effector memory T cells, both functionally and transcriptionally. Since the discovery of TRM, most research has focused on CD8+TRM, despite that CD4+TRMare also abundant in most tissues. In the past few years, more evidence has emerged that CD4+TRMcan contribute both protective and pathogenic roles in disease. A complexity inherent to the CD4+TRMfield is the ability of CD4+T cells to polarize into a multitude of distinct subsets and recognize not only viruses and intracellular bacteria but also extracellular bacteria, fungi, and parasites. In this review, we outline the key features of CD4+TRMin health and disease, including their contributions to protection against SARS-CoV-2 and potential contributions to immunopathology associated with COVID-19.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
General Medicine,Immunology
Cited by
16 articles.
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