XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells

Author:

Wahida Adam12ORCID,Müller Madeleine3ORCID,Hiergeist Andreas4ORCID,Popper Bastian5ORCID,Steiger Katja67ORCID,Branca Caterina12ORCID,Tschurtschenthaler Markus28,Engleitner Thomas29,Donakonda Sainitin310ORCID,De Coninck Jordy1112,Öllinger Rupert29ORCID,Pfautsch Marie K.3,Müller Nicole1,Silva Miguel29ORCID,Usluer Sinem1314ORCID,Thiele Orberg Erik12ORCID,Böttcher Jan P.3,Pfarr Nicole6ORCID,Anton Martina3ORCID,Slotta-Huspenina Julia B.6ORCID,Nerlich Andreas G.15ORCID,Madl Tobias1314ORCID,Basic Marijana16ORCID,Bleich André16ORCID,Berx Geert1112ORCID,Ruland Jürgen217ORCID,Knolle Percy A.310ORCID,Rad Roland29ORCID,Adolph Timon E.18,Vandenabeele Peter1920ORCID,Kanegane Hirokazu21ORCID,Gessner André4ORCID,Jost Philipp J.122,Yabal Monica3ORCID

Affiliation:

1. Medical Department III for Hematology and Oncology, TUM School of Medicine, Technical University of Munich, Munich, Germany.

2. TranslaTUM, Center for Translational Cancer Research, Munich, Germany.

3. Institute of Molecular Immunology and Experimental Oncology, TUM School of Medicine, Technical University of Munich, Munich, Germany.

4. Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.

5. Biomedical Center, Core Facility Animal Models, Ludwig-Maximilians-University, Planegg-Martinsried, Germany.

6. Institute of Pathology and Pathological Anatomy, Technical University of Munich, Munich, Germany.

7. Comparative Experimental Pathology and Digital Pathology, Institute for Pathology and Pathological Anatomy, Technical University of Munich, Munich, Germany.

8. Institute of Translational Cancer Research and Experimental Cancer Therapy, TUM School of Medicine, Technical University of Munich, Munich, Germany.

9. Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technical University of Munich, Munich, Germany.

10. German Center for Infection Research (DZIF), Munich, Germany.

11. Molecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

12. Cancer Research Institute Ghent, Ghent, Belgium.

13. Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.

14. BioTechMed Graz, Graz, Austria.

15. Institute of Pathology, Academic Clinic Munich-Bogenhausen, Munich, Germany.

16. Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany.

17. Institute of Clinical Chemistry and Pathobiochemistry, TUM School of Medicine, Technical University of Munich, Munich, Germany.

18. Department of Internal Medicine I for Gastroenterology, Hepatology, and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria.

19. Cell Death and Inflammation Unit, VIB-Center for Inflammation Research (IRC), VIB, Ghent, Belgium.

20. Department of Biomedical Molecular Biology (DBMB), Ghent University, Ghent, Belgium.

21. Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

22. Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria.

Abstract

In XIAP deficiency, ileitis is driven by TNFR1- and TNFR2-dependent targeting of TLR5-expressing Paneth and dendritic cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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