Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection-Reference-Cited by-同舟云学术

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

Published:2021-05-28 Issue:59 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Ma Lina¹^ORCID,Sahu Sanjaya K.¹^ORCID,Cano Marlene¹^ORCID,Kuppuswamy Vasanthan²,Bajwa Jamal¹³,McPhatter Ja’Nia¹⁴^ORCID,Pine Alexander⁵^ORCID,Meizlish Matthew L.⁶^ORCID,Goshua George⁵^ORCID,Chang C. Hong⁷,Zhang Hanming⁷^ORCID,Price Christina⁸,Bahel Parveen⁹,Rinder Henry⁹,Lei Tingting¹⁰,Day Aaron¹¹^ORCID,Reynolds Daniel¹,Wu Xiaobo¹²,Schriefer Rebecca¹²^ORCID,Rauseo Adriana M.¹³^ORCID,Goss Charles W.¹⁴^ORCID,O’Halloran Jane A.¹³^ORCID,Presti Rachel M.¹³^ORCID,Kim Alfred H.¹²^ORCID,Gelman Andrew E.¹⁰¹⁴^ORCID,Dela Cruz Charles S.¹⁵,Lee Alfred I.⁵^ORCID,Mudd Philip A.¹¹^ORCID,Chun Hyung J.⁷^ORCID,Atkinson John P.¹²,Kulkarni Hrishikesh S.¹^ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

2. Division of Hospital Medicine, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

3. Marian University, Indianapolis, IN, USA.

4. University of Pittsburgh, Pittsburgh, PA, USA.

5. Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

6. Yale School of Medicine, New Haven, CT, USA.

7. Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

8. Section of Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

9. Yale New Haven Health System, New Haven, CT, USA.

10. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

11. Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.

12. Division of Rheumatology, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

13. Division of Infectious Diseases, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

14. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.

15. Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Abstract

Increased complement activation is observed in COVID-19 compared with non-COVID respiratory illness and is a key marker of organ failure.

Funder

National Heart, Lung, and Blood Institute

National Eye Institute

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Robert E. Leet and Clara Guthrie Patterson Trust

American Heart Association

Emergency Medicine Foundation

Foundation for Barnes-Jewish Hospital

Institute of Clinical and Translational Sciences

Children’s Discovery Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference63 articles.

1. Immunology of COVID-19: Current State of the Science

2. Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies

3. Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

4. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

5. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)

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