Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity

Author:

Kokaji Toshiya1ORCID,Hatano Atsushi12ORCID,Ito Yuki34ORCID,Yugi Katsuyuki1256ORCID,Eto Miki1,Morita Keigo1,Ohno Satoshi1ORCID,Fujii Masashi178ORCID,Hironaka Ken-ichi1ORCID,Egami Riku3,Terakawa Akira1,Tsuchiya Takaho910ORCID,Ozaki Haruka910ORCID,Inoue Hiroshi11,Uda Shinsuke4ORCID,Kubota Hiroyuki4ORCID,Suzuki Yutaka3ORCID,Ikeda Kazutaka1213,Arita Makoto121314ORCID,Matsumoto Masaki15ORCID,Nakayama Keiichi I.16ORCID,Hirayama Akiyoshi17ORCID,Soga Tomoyoshi17,Kuroda Shinya1318ORCID

Affiliation:

1. Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

2. Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

3. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.

4. Division of Integrated Omics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

5. Institute for Advanced Biosciences, Keio University, Fujisawa 252-8520, Japan.

6. PRESTO, Japan Science and Technology Agency, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

7. Molecular Genetics Research Laboratory, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

8. Department of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima city, Hiroshima 739-8526, Japan.

9. Bioinformatics Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

10. Center for Artificial Intelligence Research, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.

11. Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan.

12. Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

13. Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.

14. Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan.

15. Department of Omics and Systems Biology, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibancho, Asahimachi-dori, Chuo Ward, Niigata City 951-8510, Japan.

16. Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

17. Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, Japan.

18. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan.

Abstract

Obesity shifts glucose-responsive hepatic metabolism from rapid regulation by metabolites to slower changes in gene expression.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Core Research for Evolutional Science and Technology, Japan Science and Technology Agency

Adaptable and Seamless Technology Transfer Program through Target-Driven R and D

Japan Science and Technology Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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