Rewiring of Transcriptional Regulatory Networks: Hierarchy, Rather Than Connectivity, Better Reflects the Importance of Regulators-Reference-Cited by-同舟云学术

Rewiring of Transcriptional Regulatory Networks: Hierarchy, Rather Than Connectivity, Better Reflects the Importance of Regulators

Published:2010-11-02 Issue:146 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Bhardwaj Nitin¹,Kim Philip M.²³⁴⁵,Gerstein Mark B.¹⁶⁷

Affiliation:

1. Program in Computational Biology and Bioinformatics, Yale University, Bass 426, 266 Whitney Avenue, New Haven, CT 06520, USA.

2. Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Medical Research, University of Toronto, Toronto, Ontario, Canada M5S 3E1.

3. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada M5S 3E1.

4. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 3E1.

5. Department of Computer Science, University of Toronto, Toronto, Ontario, Canada M5S 3E1.

6. Department of Molecular Biophysics and Biochemistry, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA.

7. Department of Computer Science, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA.

Abstract

Transcriptional regulatory networks appear to have an organization similar to a corporation, with top-level managers having the most influence.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference51 articles.

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