Bacterial d -amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells-Reference-Cited by-同舟云学术

Bacterial d -amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells

Published:2017-09-05 Issue:495 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Lee Robert J.¹²^ORCID,Hariri Benjamin M.¹,McMahon Derek B.¹^ORCID,Chen Bei¹,Doghramji Laurel¹^ORCID,Adappa Nithin D.¹,Palmer James N.¹,Kennedy David W.¹^ORCID,Jiang Peihua³^ORCID,Margolskee Robert F.³^ORCID,Cohen Noam A.¹³⁴^ORCID

Affiliation:

1. Department of Otorhinolaryngology—Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

2. Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

3. Monell Chemical Senses Center, Philadelphia, PA 19104, USA.

4. Philadelphia Veterans Affairs Medical Center Surgical Service, Philadelphia, PA 19104, USA.

Abstract

Staphylococcus -derived d -amino acids reduce innate immune responses in the nasal epithelium by stimulating the sweet taste receptor.

Funder

National Institute on Deafness and Other Communication Disorders

Cystic Fibrosis Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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