The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype–specific therapeutic target for ovarian cancer

Author:

Antony Jane123,Tan Tuan Zea1,Kelly Zoe3,Low Jeffrey4,Choolani Mahesh4,Recchi Chiara3,Gabra Hani3,Thiery Jean Paul156,Huang Ruby Yun-Ju147

Affiliation:

1. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

2. NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore.

3. Department of Surgery and Cancer, Imperial College London, London W120NN, U.K.

4. Department of Obstetrics and Gynecology, National University Health System, Singapore 119228, Singapore.

5. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.

6. Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.

7. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

Abstract

AXL inhibitors may prolong survival in a subset of patients with advanced ovarian cancer.

Funder

National Research Foundation Singapore

Singapore Ministry of Education

National Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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