PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins-Reference-Cited by-同舟云学术

PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

Published:2018-06-19 Issue:535 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Li Lili¹²^ORCID,Zhao Hui³,Liu Ping¹,Li Chunfeng⁴⁵,Quanquin Natalie⁶^ORCID,Ji Xue³^ORCID,Sun Nina¹²,Du Peishuang¹,Qin Cheng-Feng³,Lu Ning¹^ORCID,Cheng Genhong⁴⁵⁶^ORCID

Affiliation:

1. CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China.

2. University of Chinese Academy of Sciences, Beijing 100101, China.

3. Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 10071, China.

4. Center for System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

5. Suzhou Institute of System Medicine, Suzhou, Jiangsu 215123, China.

6. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.

Abstract

Interferon stimulates the ADP-ribosylation–dependent degradation of nonstructural Zika virus proteins necessary for viral replication.

Funder

MOST

the NSFC

The CAMS Initiative for Innovative Medicine

The National Science and Technology Major Project for ’’Significant New Drugs Innovation and Development

The State Key Laboratory of Pathogen and Biosecurity

The NSFC Excellent Young Scientist Award

The Innovative Research Group