PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling-Reference-Cited by-同舟云学术

PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling

Published:2020-03-17 Issue:623 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Yang Shen¹^ORCID,Svensson Mattias N. D.¹^ORCID,Harder Nathaniel H. O.¹²^ORCID,Hsieh Wan-Chen¹,Santelli Eugenio¹^ORCID,Kiosses William B.³^ORCID,Moresco James J.⁴^ORCID,Yates John R.⁴^ORCID,King Charles C.⁵,Liu Lin⁶⁷,Stanford Stephanie M.¹²,Bottini Nunzio¹²^ORCID

Affiliation:

1. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

2. Division of Cellular Biology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA

3. Core Microscopy, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

4. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

5. Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

6. Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, 92037, USA.

7. Veterans Affairs San Diego Healthcare System, San Diego, CA 90026, USA.

Abstract

Phosphorylation of PTPN22 at Ser 751 balances phosphatase degradation and plasma membrane recruitment.

Funder

American Diabetes Association

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. Protein tyrosine phosphatases: from genes, to function, to disease

2. Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease

3. PTPN22: the archetypal non-HLA autoimmunity gene

4. PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells

5. Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

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