AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer-Reference-Cited by-同舟云学术

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Published:2011-08-30 Issue:188 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chan Joanna C.¹,Hannan Katherine M.¹,Riddell Kim¹,Ng Pui Yee¹,Peck Abigail¹,Lee Rachel S.¹,Hung Sandy¹,Astle Megan V.¹,Bywater Megan¹,Wall Meaghan¹²³,Poortinga Gretchen¹²,Jastrzebski Katarzyna¹,Sheppard Karen E.¹,Hemmings Brian A.⁴,Hall Michael N.⁵,Johnstone Ricky W.¹,McArthur Grant A.¹²⁶,Hannan Ross D.¹⁶⁷,Pearson Richard B.¹⁶⁷⁸

Affiliation:

1. Division of Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 8006, Australia.

2. Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.

3. Victorian Cancer Cytogenetics Service, St Vincent’s Hospital, Melbourne, Victoria 8006, Australia.

4. Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.

5. Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

6. Department of Medicine, St Vincent’s Hospital, Melbourne, Victoria 8006, Australia.

7. Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria 3010, Australia.

8. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia.

Abstract

In addition to promoting translation, AKT also stimulates protein synthesis and cell growth by enhancing ribosome biogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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