BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons-Reference-Cited by-同舟云学术

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

Published:2019-06-18 Issue:586 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Afonso Pedro¹²^ORCID,De Luca Pasqualino¹³^ORCID,Carvalho Rafael S.¹^ORCID,Cortes Luísa¹³^ORCID,Pinheiro Paulo¹³^ORCID,Oliveiros Barbara⁴⁵^ORCID,Almeida Ramiro D.¹⁶^ORCID,Mele Miranda¹³^ORCID,Duarte Carlos B.¹⁷^ORCID

Affiliation:

1. CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

2. Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.

3. Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3030-790 Coimbra, Portugal.

4. Laboratory of Biostatistics and Medical Informatics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

5. Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

6. Health Sciences Program, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.

7. Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal.

Abstract

The RNA binding protein hnRNP K mediates BDNF-induced proteome remodeling at the neuronal synapse.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference74 articles.

1. BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

2. Neurotrophin regulation of neural circuit development and function

3. TrkB signalling pathways in LTP and learning

4. BDNF-induced local protein synthesis and synaptic plasticity

5. BDNF and Hippocampal Synaptic Plasticity

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