Mechanobiology of the SkeletonA presentation from the Keystone Symposium Mechanotransduction in Physiology and Disease in Taos, New Mexico, 18 to 23 January 2009.-Reference-Cited by-同舟云学术

Mechanobiology of the SkeletonA presentation from the Keystone Symposium Mechanotransduction in Physiology and Disease in Taos, New Mexico, 18 to 23 January 2009.

Published:2009-04-28 Issue:68 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Turner Charles H.¹,Warden Stuart J.²,Bellido Teresita³,Plotkin Lilian I.³,Kumar Natarajan⁴,Jasiuk Iwona⁴,Danzig Jon⁴,Robling Alexander G.³

Affiliation:

1. Departments of Orthopaedic Surgery and Biomedical Engineering, IUPUI, Indianapolis, IN 46202, USA.

2. Department of Physical Therapy, Indiana University, Indianapolis, IN 46202, USA.

3. Department of Anatomy and Cell Biology, Indiana University, Indianapolis, IN 46202, USA.

4. Department of Mechanical Engineering, University of Illinois, Champaign-Urbana, IL 61801, USA.

Abstract

Mechanical force induces osteogenesis by repressing the production of sclerostin, an inhibitor of Wnt signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference23 articles.

1. Mechanisms of Anabolic Therapies for Osteoporosis

2. ATP- and Gap Junction–dependent Intercellular Calcium Signaling in Osteoblastic Cells

3. Humeral hypertrophy in response to exercise

4. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure

5. Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force

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