Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload-Reference-Cited by-同舟云学术

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Published:2019-06-25 Issue:587 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Nishimura Akiyuki¹²³^ORCID,Shimoda Kakeru²³⁴^ORCID,Tanaka Tomohiro²³⁵^ORCID,Toyama Takashi³^ORCID,Nishiyama Kazuhiro¹,Shinkai Yasuhiro⁶,Numaga-Tomita Takuro²³⁴,Yamazaki Daiju⁷,Kanda Yasunari⁷,Akaike Takaaki⁸,Kumagai Yoshito⁶,Nishida Motohiro¹²³⁴^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

2. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.

3. National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.

4. SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.

5. Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.

6. Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.

7. Division of Pharmacology, National Institute of Health Sciences, Kanagawa, 210-9501, Japan.

8. Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.

Abstract

Methylmercury precipitates heart failure by increasing Drp1-mediated mitochondrial fission.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. The basics of thiols and cysteines in redox biology and chemistry

2. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

3. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

4. Protein S-sulfhydration by hydrogen sulfide in cardiovascular system

5. Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes;Journal of Pharmacological Sciences;2024-10

2. Supersulfide catabolism participates in maladaptive remodeling of cardiac cells;Journal of Pharmacological Sciences;2024-08

3. Sulfur metabolism as a new therapeutic target of heart failure;Journal of Pharmacological Sciences;2024-07

4. Supersulphides suppress type-I and type-II interferon responses by blocking JAK/STAT signalling in macrophages;International Immunology;2024-06-20

5. Inhibition of Drp1–Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria–Lipid Droplet Contact;International Journal of Molecular Sciences;2024-05-17