The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

Author:

Tang Fengyuan12,Gill Jason1,Ficht Xenia3,Barthlott Thomas4,Cornils Hauke1,Schmitz-Rohmer Debora1,Hynx Debby1,Zhou Dawang5,Zhang Lei1,Xue Gongda12,Grzmil Michal1,Yang Zhongzhou6,Hergovich Alexander7,Hollaender Georg A.4,Stein Jens V.3,Hemmings Brian A.1,Matthias Patrick18

Affiliation:

1. Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.

2. Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.

3. Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.

4. Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel and Basel University Children’s Hospital, 4058 Basel, Switzerland.

5. State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, 361006 Xiamen, China.

6. MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210061 Nanjing, China.

7. UCL Cancer Institute, WC1E 6BT London, UK.

8. Faculty of Science, University of Basel, 4003 Basel, Switzerland.

Abstract

Signaling by kinases downstream of the Hippo homolog mediates thymocyte migration.

Funder

Swiss Cancer League

Swiss National Science Foundation

Wellcome Trust Research Career Development

Novartis Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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