Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

Author:

Zhang Huabing1,Ramakrishnan Sadeesh K.1,Triner Daniel1,Centofanti Brook1,Maitra Dhiman1,Győrffy Balázs2,Sebolt-Leopold Judith S.3,Dame Michael K.4,Varani James4,Brenner Dean E.4,Fearon Eric R.456,Omary M. Bishr167,Shah Yatrik M.16

Affiliation:

1. Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

2. MTA TTK Lendület Cancer Biomarker Research Group, MTA-SE Pediatrics and Nephrology Research Group, Semmelweis University 2nd Department of Pediatrics, Budapest H-1117, Hungary.

3. Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

4. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

5. Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

6. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

7. Department of Veterans Affairs Ann Arbor Health Care System, Ann Arbor, MI 48105, USA.

Abstract

In an oxygen- and nutrient-deprived environment, verteporfin kills colon cancer cells by inducing proteotoxicity.

Funder

NIH

University of Michigan Gastrointestinal Peptide Research Center

OTKA (Hungarian Scientific Research Fund)

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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