Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Author:

DeBosch Brian J.1,Heitmeier Monique R.1,Mayer Allyson L.1,Higgins Cassandra B.1,Crowley Jan R.2,Kraft Thomas E.1,Chi Maggie3,Newberry Elizabeth P.2,Chen Zhouji2,Finck Brian N.2,Davidson Nicholas O.2,Yarasheski Kevin E.2,Hruz Paul W.1,Moley Kelle H.3

Affiliation:

1. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

The disaccharide trehalose blocks glucose uptake in hepatocytes and induces autophagy that prevents fatty liver disease.

Funder

Washington University Child Health Research Center

Children's Discovery Institute

Robert Wood Johnson Foundation

American Gastroenterological Association

Gilead Sciences Research Scholar Award in Liver Disease

Pediatric Scientist Development Program

Nutrition Obesity Research Center

Washington University Digestive Disease Research Core Center

American Heart Association

Washington University S. T. Olin Fellowship

Washington University NIGMS

Institutional Training Grant in Cell and Molecular Biosciences

NSF Graduate Student Fellowship

Washington University Biomedical Mass Spectrometry Research Facility

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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