Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins-Reference-Cited by-同舟云学术

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

Published:2017-09-05 Issue:495 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

White Katharine A.¹^ORCID,Ruiz Diego Garrido²^ORCID,Szpiech Zachary A.³^ORCID,Strauli Nicolas B.³^ORCID,Hernandez Ryan D.³⁴⁵,Jacobson Matthew P.²^ORCID,Barber Diane L.¹^ORCID

Affiliation:

1. Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.

3. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.

4. Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

High intracellular pH in cancer cells enables the oncogenic effects of Arg-to-His mutations in proteins.

Funder

National Institutes of Health

National Human Genome Research Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference38 articles.

1. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

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4. Dysregulated pH: a perfect storm for cancer progression

5. Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

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