Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition

Author:

Wang Wangsheng12,Guo Chunming3,Zhu Ping4,Lu Jiangwen12,Li Wenjiao12,Liu Chao12,Xie Huiliang1,Myatt Leslie3,Chen Zi-jiang12,Sun Kang12

Affiliation:

1. Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, P. R. China.

2. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, P. R. China.

3. Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

4. Department of Obstetrics and Gynecology, No. 401 Hospital, Qingdao 266100, P. R. China.

Abstract

Activation of the transcription factor STAT3 promotes the feed-forward production of prostaglandins in response to cortisol during labor.

Funder

National Natural Science Foundation of China

National Key Basic Research Program of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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