Linear Motif Atlas for Phosphorylation-Dependent Signaling

Author:

Miller Martin Lee12,Jensen Lars Juhl23,Diella Francesca3,Jørgensen Claus4,Tinti Michele5,Li Lei6,Hsiung Marilyn4,Parker Sirlester A.7,Bordeaux Jennifer7,Sicheritz-Ponten Thomas1,Olhovsky Marina4,Pasculescu Adrian4,Alexander Jes8,Knapp Stefan9,Blom Nikolaj1,Bork Peer210,Li Shawn6,Cesareni Gianni5,Pawson Tony4,Turk Benjamin E.7,Yaffe Michael B.8,Brunak Søren12,Linding Rune4811

Affiliation:

1. Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark.

2. The Novo Nordisk Foundation Centre for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark.

3. European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

4. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, M5G 1X5 Toronto, Ontario, Canada.

5. University of Rome, Tor Vergata, 00133 Rome, Italy.

6. University of Western Ontario, N6A 5C1 London, Ontario, Canada.

7. Department of Pharmacology, Yale University School of Medicine, New Haven, 06520 CT, USA.

8. Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 021329 MA, USA.

9. Structural Genomics Consortium, University of Oxford, OX3 7DQ Oxford, UK.

10. Max-Delbrück-Centre for Molecular Medicine, 13092 Berlin, Germany.

11. Cellular & Molecular Logic Team, The Institute of Cancer Research, SW3 6JB London, UK.

Abstract

Created with both in vitro and in vivo data, NetPhorest is an atlas of consensus sequence motifs for 179 kinases and 104 phosphorylation-dependent binding domains and reveals new insight into phosphorylation-dependent signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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