BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1-Reference-Cited by-同舟云学术

BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1

Published:2020-07-07 Issue:639 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Anastasi Cyril¹^ORCID,Rousselle Patricia¹^ORCID,Talantikite Maya¹,Tessier Agnès¹^ORCID,Cluzel Caroline¹^ORCID,Bachmann Alice¹,Mariano Natacha¹,Dussoyer Mélissa¹^ORCID,Alcaraz Lindsay B.²,Fortin Laëtitia¹^ORCID,Aubert Alexandre¹,Delolme Frédéric¹³^ORCID,El Kholti Naïma¹,Armengaud Jean⁴^ORCID,Fournié Pierre⁵⁶^ORCID,Auxenfans Céline¹⁷^ORCID,Valcourt Ulrich¹²^ORCID,Goff Sandrine Vadon-Le¹^ORCID,Moali Catherine¹^ORCID

Affiliation:

1. University of Lyon, CNRS UMR 5305, Tissue Biology and Therapeutic Engineering Laboratory (LBTI), F-69367 Lyon, France.

2. University of Lyon, Centre Léon Bérard, INSERM U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), F-69373 Lyon, France.

3. University of Lyon, ENS de Lyon, INSERM US8, CNRS UMS3444, SFR Biosciences, F-69366 Lyon, France.

4. CEA Marcoule, Innovative Technologies for Detection and Diagnostics Laboratory (DRF/Joliot/DMTS/SPI/Li2D), F-30200 Bagnols-sur-Cèze, France.

5. Purpan University Hospital, Ophthalmology Department, F-31059 Toulouse, France.

6. University of Toulouse, CNRS UMR 5165, INSERM U1056, Epithelial Differentiation and Rheumatoid Autoimmunity Unit (UDEAR), F-31059 Toulouse, France.

7. Hospices Civils de Lyon, Tissue and Cell Bank, F-69437 Lyon, France.

Abstract

BMP-1–mediated cleavage of TSP-1 reduces cell adhesion and promotes TGF-β signaling.

Funder

Agence Nationale de la Recherche

Ligue Contre le Cancer

Centre National de la Recherche Scientifique

Université Claude Bernard Lyon 1

Région Auvergne-Rhône-Alpes

Publisher

American Association for the Advancement of Science (AAAS)

Subject