Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye-Reference-Cited by-同舟云学术

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Published:2018-07-31 Issue:541 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sakurai Tetsuya¹^ORCID,Uruno Takehito¹²^ORCID,Sugiura Yuki³⁴,Tatsuguchi Takaaki¹,Yamamura Kazuhiko¹,Ushijima Miho¹,Hattori Yuko³,Kukimoto-Niino Mutsuko⁵,Mishima-Tsumagari Chiemi⁵,Watanabe Mayuki¹,Suematsu Makoto³^ORCID,Fukui Yoshinori¹²^ORCID

Affiliation:

1. Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

2. Research Center for Advanced Immunology, Kyushu University, Fukuoka 812-8582, Japan.

3. Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan.

4. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan.

5. RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan.

Abstract

A modified form of cholesterol protects the eye from immune cell invasion by inhibiting the Rac-specific GEF DOCK2.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science, and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference55 articles.

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5. Creating immune privilege: active local suppression that benefits friends, but protects foes

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