ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3-Reference-Cited by-全球学者库

ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3

Published:2022-01-04 Issue:715 Volume:15 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Yu Congci¹^ORCID,Wang Bei¹^ORCID,Zhu Yue¹,Zhang Chongyang¹^ORCID,Ren Lili²,Lei Xiaobo²,Xiang Zichun²,Zhou Zhuo³^ORCID,Huang He¹^ORCID,Wang Jianwei²^ORCID,Zhao Zhendong¹⁴⁵^ORCID

Affiliation:

1. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

2. NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

3. Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking University Genome Editing Research Center, School of Life Sciences,, Peking University, Beijing, China.

4. Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

5. CAMS-Oxford University International Center for Translational Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract

ID2 reduces the interferon response to viral infections by inhibiting the activation of IRF3.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference49 articles.

1. Innate Immune Recognition

2. Cytosolic Sensing of Viruses

3. Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids

4. Type I interferons in infectious disease

5. Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism

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