Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth-Reference-Cited by-全球学者库

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Published:2009-11-17 Issue:97 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hitosugi Taro¹,Kang Sumin¹,Vander Heiden Matthew G.²,Chung Tae-Wook¹,Elf Shannon¹,Lythgoe Katherine¹,Dong Shaozhong¹,Lonial Sagar¹,Wang Xu¹,Chen Georgia Z.¹,Xie Jianxin³,Gu Ting-Lei³,Polakiewicz Roberto D.³,Roesel Johannes L.⁴,Boggon Titus J.⁵,Khuri Fadlo R.¹,Gilliland D. Gary⁶,Cantley Lewis C.²,Kaufman Jonathan¹,Chen Jing¹

Affiliation:

1. Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

2. Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.

3. Cell Signaling Technology, Inc. (CST), Danvers, MA 01923, USA.

4. Novartis Pharma AG, CH-4002 Basel, Switzerland.

5. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

6. Howard Hughes Medical Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

Abstract

Tyrosine phosphorylation of pyruvate kinase M2 gives tumor cells a metabolic advantage.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference25 articles.

1. Hypoxia signalling controls metabolic demand

2. Tumor Cell Metabolism: Cancer's Achilles' Heel

3. The Hallmarks of Cancer

4. Current Status of Tumor M2 Pyruvate Kinase (Tumor M2-PK) as a Biomarker of Gastrointestinal Malignancy

5. Pyruvate kinase type M2 and its role in tumor growth and spreading

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