The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation-Reference-Cited by-同舟云学术

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

Published:2018-01-02 Issue:511 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Shim Sang Mi¹²^ORCID,Choi Ha Rim¹²,Sung Ki Woon¹²^ORCID,Lee Yoon Jee¹²^ORCID,Kim Sung Tae¹²³^ORCID,Kim Daeho¹⁴,Mun Su Ran¹²^ORCID,Hwang Joonsung⁵,Cha-Molstad Hyunjoo⁵^ORCID,Ciechanover Aaron¹⁶^ORCID,Kim Bo Yeon⁵^ORCID,Kwon Yong Tae¹²⁷^ORCID

Affiliation:

1. Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2. Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

3. Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.

4. Department of Biophysics and Chemical Biology, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.

5. World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 28116, Republic of Korea.

6. Tumor and Vascular Biology Research Center, Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa 31096, Israel.

7. Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

Abstract

N-terminal arginylation in response to various stresses causes the ER chaperone BiP to relocate to and be degraded in the cytosol.

Funder

Ministry of Science, ICT, and Future Planning (MSIP), Republic of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference67 articles.

1. Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

2. The endoplasmic reticulum as a protein-folding compartment