A Wnt-Bmp Feedback Circuit Controls Intertissue Signaling Dynamics in Tooth Organogenesis

Author:

O’Connell Daniel J.1,Ho Joshua W. K.12,Mammoto Tadanori3,Turbe-Doan Annick1,O’Connell Joyce T.4,Haseley Psalm S.12,Koo Samuel15,Kamiya Nobuhiro6,Ingber Donald E.378,Park Peter J.129,Maas Richard L.1

Affiliation:

1. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

3. Vascular Biology Program, Children’s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

4. Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

5. Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.

6. Center for Excellence in Hip Disorders, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA.

7. Wyss Institute for Biologically Inspired Engineering at Harvard University, Wyss Institute, Boston, MA 02115, USA.

8. Department of Engineering and Applied Sciences, Harvard School of Engineering and Applied Sciences, Cambridge, MA 02139, USA.

9. Informatics Program, Children’s Hospital Boston, Boston, MA 02115, USA.

Abstract

Computational and genetic analyses reveal a key circuit involving Wnt and Bmp in developing teeth in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference49 articles.

1. Morphogenetic Interaction between Embryonic Mouse Tissues separated by a Membrane Filter

2. Mechanisms of organogenetic tissue interaction.;Grobstein C.;Natl. Cancer Inst. Monogr.,1967

3. Epithelial-mesenchymal interactions in murine organogenesis.;Saxén L.;Ciba Found. Symp.,1992

4. Inductive Processes in Embryonic Development

5. Embryonic induction — molecular prospects

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