The HDAC3–SMARCA4–miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma

Author:

Bharathy Narendra1,Berlow Noah E.1ORCID,Wang Eric2,Abraham Jinu3ORCID,Settelmeyer Teagan P.1,Hooper Jody E.4ORCID,Svalina Matthew N.1,Ishikawa Yoshihiro5ORCID,Zientek Keith5,Bajwa Zia16,Goros Martin W.7ORCID,Hernandez Brian S.7ORCID,Wolff Johannes E.8,Rudek Michelle A.91011,Xu Linping910,Anders Nicole M.910,Pal Ranadip12,Harrold Alexandria P.1ORCID,Davies Angela M.13,Ashok Arya13ORCID,Bushby Darnell13,Mancini Maria13ORCID,Noakes Christopher13,Goodwin Neal C.13ORCID,Ordentlich Peter14ORCID,Keck James15,Hawkins Douglas S.16ORCID,Rudzinski Erin R.16,Chatterjee Bishwanath17ORCID,Bächinger Hans Peter518,Barr Frederic G.17,Liddle Jennifer19,Garcia Benjamin A.19,Mansoor Atiya6,Perkins Theodore J.2021,Vakoc Christopher R.2,Michalek Joel E.7ORCID,Keller Charles1ORCID

Affiliation:

1. Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.

2. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

3. Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

4. Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

5. Research Center, Shriners Hospital for Children, Portland, OR 97239, USA.

6. Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA.

7. Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX 78229, USA.

8. Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic Children’s, Cleveland, OH 44195, USA.

9. Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.

10. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21224, USA.

11. Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.

12. Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA.

13. Champions Oncology, Rockville, MD 20850, USA.

14. Syndax Pharmaceuticals, Waltham, MA 02451, USA.

15. The Jackson Laboratory, Sacramento, CA 95838, USA.

16. Seattle Children’s Hospital, Seattle, WA 98105, USA.

17. Cancer Molecular Pathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892-1500, USA.

18. Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239, USA.

19. Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.

20. Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa K1H 8L6, Canada.

21. Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa K1H 8M5, Canada.

Abstract

The HDAC inhibitor entinostat sensitizes a subset of rhabdomyosarcomas to chemotherapy.

Funder

National Institutes of Health

St. Baldrick’s Foundation

Michelle Paternoster Foundation for Sarcoma Research

Christina Renna Foundation

Friends of T.J. Foundation

Clarke Gilles Foundation

Friends of Doernbecher

Braver, Stronger, Smarter

Intramural Research Program of the National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference33 articles.

1. L. E. Davis C. Keller “Integrative biology of rhabdomyosarcoma using genetic murine models ” AACR 2012 Annual Meeting Educational Book (2012).

2. Declining childhood and adolescent cancer mortality

3. National Institutes of Health National Cancer Institute U.S. Department of Health and Human Services National Cancer Institute LiveStrong Young Adult Alliance “Closing the gap: Research and care imperatives for adolescents and young adults with cancer report of the Adolescent and Young Adult Oncology Progress Review Group” (NIH Publication No. 06-6067 National Cancer Institute 2006).

4. Prognostic Factors and Clinical Outcomes in Children and Adolescents With Metastatic Rhabdomyosarcoma—A Report From the Intergroup Rhabdomyosarcoma Study IV

5. Rhabdomyosarcoma: Review of the Children's Oncology Group (COG) soft-tissue Sarcoma committee experience and rationale for current COG studies

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