Modulation of Cl − signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT

Author:

Vachel Laura1,Shcheynikov Nikolay1,Yamazaki Osamu12,Fremder Moran3,Ohana Ehud3,Son Aran1ORCID,Shin Dong Min4ORCID,Yamazaki-Nakazawa Ai1,Yang Chin-Rang5,Knepper Mark A.5ORCID,Muallem Shmuel1

Affiliation:

1. Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

2. Apheresis and Dialysis Center/General Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-0016, Japan.

3. Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.

4. Department of Oral Biology, BK 21 PLUS Project, Yonsei University College of Dentistry, Seoul 120-752, Korea.

5. Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Different phosphorylation patterns regulate the activity of an epithelial transporter and its sensitivity to Cl .

Funder

National Heart, Lung, and Blood Institute

National Institute of Dental and Craniofacial Research

United States-Israel Binational Science Foundation

National Research Foundation of Korea

Israel Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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