Analysis of neural crest–derived clones reveals novel aspects of facial development

Author:

Kaucka Marketa1,Ivashkin Evgeny12,Gyllborg Daniel3,Zikmund Tomas4,Tesarova Marketa4ORCID,Kaiser Jozef4ORCID,Xie Meng1,Petersen Julian5,Pachnis Vassilis6,Nicolis Silvia K.7ORCID,Yu Tian8,Sharpe Paul8,Arenas Ernest3ORCID,Brismar Hjalmar9ORCID,Blom Hans9ORCID,Clevers Hans10,Suter Ueli11,Chagin Andrei S.1,Fried Kaj12ORCID,Hellander Andreas13,Adameyko Igor15

Affiliation:

1. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-171 77, Sweden.

2. Research Center of Neurology, 125367 Moscow, Russia.

3. Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-171 77, Sweden.

4. Central European Institute of Technology, Brno University of Technology, 616 00 Brno, Czech Republic.

5. Department of Molecular Neurosciences, Medical University of Vienna, Vienna 1190, Austria.

6. Division of Molecular Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK.

7. Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.

8. Department of Craniofacial Development and Stem Cell Biology, King’s College London Dental Institute, Guy’s Hospital, London SE1 9RT, UK.

9. Science for Life Laboratory, Royal Institute of Technology, Solna 17121, Sweden.

10. Hubrecht Institute of the Royal Netherlands Academy of Arts and Sciences, Princess Maxima Centre and University Medical Centre Utrecht, 3584 Utrecht, Netherlands.

11. Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich CH-8093, Switzerland.

12. Department of Neuroscience, Karolinska Institutet, Stockholm SE-171 77, Sweden.

13. Department of Information Technology, Uppsala University, Uppsala SE-751 05, Sweden.

Abstract

Facial shaping results from oriented divisions and crowd movements of ectomesenchymal cells during morphogenetic events.

Funder

Ake Wiberg Foundation

Bertil Hallsten Research Foundation

European Molecular Biology Organization

Vetenskapsrådet

Russian Fund for Basic Research

Ministry of Education, Youth and Sports of the Czech Republic

Swiss National Science Foundation

Swedish strategic research programme eSSENCE

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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