Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis-Reference-Cited by-同舟云学术

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

Published:2016-07 Issue:7 Volume:2 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Karunakaran Denuja¹^ORCID,Geoffrion Michele¹,Wei Lihui¹²,Gan Wei¹²^ORCID,Richards Laura¹,Shangari Prakriti¹,DeKemp Ella M.¹,Beanlands Rachelle A.¹,Perisic Ljubica³,Maegdefessel Lars⁴^ORCID,Hedin Ulf³,Sad Subash⁵,Guo Liang⁶^ORCID,Kolodgie Frank D.⁶^ORCID,Virmani Renu⁶,Ruddy Terrence¹²^ORCID,Rayner Katey J.¹⁵

Affiliation:

1. University of Ottawa Heart Institute, Ottawa, Ontario K1Y4W7, Canada.

2. Canadian Molecular Imaging Centre of Excellence, University of Ottawa Heart Institute, Ottawa, Ontario K1Y4W7, Canada.

3. Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm 171 76, Sweden.

4. Department of Medicine, Karolinska Institute, Stockholm 171 76, Sweden.

5. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H8L1, Canada.

6. CVPath Institute Inc., Gaithersburg, MD 20878, USA.

Abstract

Necroptosis promotes necrotic core and vulnerable atherosclerosis in humans and mice and is a prospective therapeutic and diagnostic tool.

Funder

Canadian Institutes of Health Research

National Heart, Lung, and Blood Institute