The transition from linear to highly branched poly(β-amino ester)s: Branching matters for gene delivery

Author:

Zhou Dezhong12,Cutlar Lara2,Gao Yongsheng2,Wang Wei2,O’Keeffe-Ahern Jonathan2,McMahon Sean2,Duarte Blanca3ORCID,Larcher Fernando3,Rodriguez Brian J.4ORCID,Greiser Udo2,Wang Wenxin12

Affiliation:

1. School of Materials and Engineering, Tianjin University, Tianjin 300072, China.

2. Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.

3. Cutaneous Diseases Modelling Unit, Division of Biomedicine, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid 28040, Spain.

4. School of Physics and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.

Abstract

Highly branched poly(β-amino ester) polymers are developed to carry a gene and to enter cells for the production of protein.

Funder

Science Foundation Ireland

Health Research Board

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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