The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

Author:

Ben-Avraham Danny123,Govindaraju Diddahally R.34,Budagov Temuri13,Fradin Delphine5,Durda Peter6,Liu Bing7,Ott Sandy8,Gutman Danielle9ORCID,Sharvit Lital9ORCID,Kaplan Robert10,Bougnères Pierre511,Reiner Alex1213,Shuldiner Alan R.814,Cohen Pinchas7,Barzilai Nir123,Atzmon Gil1239

Affiliation:

1. Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

2. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

3. Institute of Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

4. Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

5. INSERM U986, Pincus Building, Bicêtre Hospital, Paris Sud University, 94275 Le Kremlin Bicêtre, France.

6. Department of Pathology University of Vermont, 208 South Park Drive, Colchester, VT 05446, USA.

7. Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.

8. University of Maryland School of Medicine, Baltimore, MD 21201, USA.

9. Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.

10. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

11. INSERM U1169 and Department of Pediatric Endocrinology and Diabetes, Bicêtre Hospital, Pôle I3E, Paris Sud University, 94275 Le Kremlin Bicêtre, France.

12. Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA.

13. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

14. Geriatrics Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD 20420, USA.

Abstract

The d3-GHR genetic variant polymorphism modulates GH responsiveness throughout life span and positively affects male longevity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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