POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA-Reference-Cited by-同舟云学术

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA

Published:2016-08-05 Issue:8 Volume:2 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kühl Inge¹,Miranda Maria¹,Posse Viktor²,Milenkovic Dusanka¹,Mourier Arnaud¹³,Siira Stefan J.⁴^ORCID,Bonekamp Nina A.¹,Neumann Ulla⁵,Filipovska Aleksandra⁴,Polosa Paola Loguercio⁶,Gustafsson Claes M.²,Larsson Nils-Göran¹⁷

Affiliation:

1. Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.

2. Department of Medical Biochemistry and Cell Biology, Göteborgs Universitet, 40530 Göteborg, Sweden.

3. Université de Bordeaux and the Centre National de la Recherche Scientifique, Institut de Biochimie et Génétique Cellulaires UMR 5095, Saint-Saëns, F-33077 Bordeaux, France.

4. Harry Perkins Institute of Medical Research, Centre for Medical Research and School of Chemistry and Biochemistry, The University of Western Australia, Perth 6009, Australia.

5. Central Microscopy, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany.

6. Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, Italy.

7. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.

Abstract

Mitochondrial transcription for replication primer formation has priority over gene expression at low POLRMT levels.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Vetenskapsrådet

Knut och Alice Wallenbergs Stiftelse

National Health and Medical Research Council

Alexander von Humboldt-Stiftung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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