Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing

Author:

Joseph Adrian1ORCID,Contini Claudia1ORCID,Cecchin Denis1ORCID,Nyberg Sophie12ORCID,Ruiz-Perez Lorena1ORCID,Gaitzsch Jens13,Fullstone Gavin14,Tian Xiaohe15ORCID,Azizi Juzaili6,Preston Jane6ORCID,Volpe Giorgio1,Battaglia Giuseppe17

Affiliation:

1. Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.

2. Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

3. Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel, Switzerland.

4. Institute for Cell Biology and Immunology, University of Stuttgart, Allmandring 31, Stuttgart 70569, Germany.

5. School of Life Sciences, Anhui University, Hefei 230039, PR China.

6. Institute of Pharmaceutical Science, Kings College London, 150 Stamford Street, London SE1 9NH, UK.

7. Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.

Abstract

Brain homing nanoswimmers: Glucose-fueled propulsion combined with blood-brain barrier crossing enhances brain delivery.

Funder

European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

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2. A Cell's Sense of Direction

3. Signal processing in complex chemotaxis pathways;Porter S. L.;Nat. Rev. Microbiol.,2011

4. Live from under the lens: Exploring microbial motility with dynamic imaging and microfluidics;Son K.;Nat. Rev. Microbiol.,2015

5. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development;Zou Y.-R.;Nature,1998

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