Structural basis for KCNE3 modulation of potassium recycling in epithelia-Reference-Cited by-同舟云学术

Structural basis for KCNE3 modulation of potassium recycling in epithelia

Published:2016-09-02 Issue:9 Volume:2 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kroncke Brett M.¹²^ORCID,Van Horn Wade D.¹²³⁴⁵,Smith Jarrod¹²^ORCID,Kang CongBao¹²⁶^ORCID,Welch Richard C.⁷,Song Yuanli¹²^ORCID,Nannemann David P.²⁸^ORCID,Taylor Keenan C.¹²^ORCID,Sisco Nicholas J.³⁴⁵^ORCID,George Alfred L.⁹,Meiler Jens²⁸,Vanoye Carlos G.⁹^ORCID,Sanders Charles R.¹²⁷

Affiliation:

1. Department of Biochemistry, Vanderbilt University, Nashville, TN 37240, USA.

2. Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.

3. School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.

4. Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.

5. Center for Personalized Diagnostics, Arizona State University, Tempe, AZ 85287, USA.

6. Experimental Therapeutics Centre, Agency for Science Technology and Research, Singapore, Singapore.

7. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, USA.

8. Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.

9. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

KCNE3 modulates the KCNQ1 K + channel in epithelia by directly stabilizing the voltage-sensor S4 segment in its activated state.

Funder

Science Foundation of Arizona

National Heart, Lung, and Blood Institute

National Institute on Deafness and Other Communication Disorders

National Institute of General Medical Sciences

National Institute of Neurological Disorders and Stroke

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference83 articles.

1. Disruption of the K+ Channel β-Subunit KCNE3 Reveals an Important Role in Intestinal and Tracheal Cl− Transport

2. A constitutively open potassium channel formed by KCNQ1 and KCNE3

3. MiRP2 Forms Potassium Channels in Skeletal Muscle with Kv3.4 and Is Associated with Periodic Paralysis

5. MinK, MiRP1, and MiRP2 Diversify Kv3.1 and Kv3.2 Potassium Channel Gating

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