Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy

Author:

Wong Terence T. W.1ORCID,Zhang Ruiying1ORCID,Hai Pengfei1,Zhang Chi1,Pleitez Miguel A.1,Aft Rebecca L.23,Novack Deborah V.45,Wang Lihong V.1ORCID

Affiliation:

1. Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

2. Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. John Cochran Veterans Hospital, St. Louis, MO 63106, USA.

4. Musculoskeletal Research Center, Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

A photoacoustic microscope system provides label-free multilayered histology-like imaging of unprocessed human breast specimens.

Funder

National Institutes of Health

Siteman Cancer Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. American Cancer Society “Breast Cancer Facts & Figures 2015–2016” (American Cancer Society Inc. 2015).

2. Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer;Moran M. S.;J. Clin. Oncol.,2014

3. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial;van Dongen J. A.;J. Natl. Cancer Inst.,2000

4. Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: Influence of margin status and systemic therapy on local recurrence;Park C. C.;J. Clin. Oncol.,2000

5. Breast conservation surgery achieving ≥ 2 mm tumor-free margins results in decreased local-regional recurrence rates;Kunos C.;Breast J.,2006

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