Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop-Reference-Cited by-全球学者库

Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop

Published:2021-03-26 Issue:6536 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bai Lu¹²^ORCID,Vienne Margaux³^ORCID,Tang Ling¹²^ORCID,Kerdiles Yann³^ORCID,Etiennot Marion³,Escalière Bertrand³,Galluso Justine³,Wei Haiming¹²⁴^ORCID,Sun Rui¹²⁴^ORCID,Vivier Eric³⁵⁶^ORCID,Peng Hui¹²⁴^ORCID,Tian Zhigang¹²⁴^ORCID

Affiliation:

1. Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

2. Institute of Immunology, University of Science and Technology of China, Hefei, China.

3. Aix Marseille Univ., CNRS, INSERM, CIML, Marseille, France.

4. Research Unit for NK Cell Study, Chinese Academy of Medical Sciences, Beijing, China.

5. APHM, Hôpital de la Timone, Marseille-Immunopole, Marseille, France.

6. Innate Pharma, Marseille, France.

Abstract

An IFN-γ feedback loop Innate lymphoid cells (ILCs) play important roles in tissue homeostasis and host defense. Type 1 ILCs (ILC1s) produce interferon-γ (IFN-γ) and require the transcriptional master regulator T-bet. The pathways underlying how these cells develop and differentiate have remained poorly understood. Bai et al. found that the adult mouse liver contains a population of Lin–Sca-1 + Mac-1 + hematopoietic stem cells (LSM HSCs) that preferentially differentiate into tissue-resident liver ILC1s. They further show that IFN-γ produced by mature ILC1s promotes the expansion and differentiation of LSM HSCs into ILC1s but not natural killer cells. This work expands our understanding of extramedullary hematopoiesis and underscores the unique immune status of the liver. Science , this issue p. eaba4177

Funder

H2020 European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

1. Hematopoietic stem cell: self-renewal versus differentiation

2. Homeostatic and pathogenic extramedullary hematopoiesis

3. The journey of developing hematopoietic stem cells

4. Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

5. Presence of hematopoietic stem cells in the adult liver

Cited by 61 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. On blood and tissue-resident natural killer cells;Immunity;2024-01

2. Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection;Immunity;2024-01

3. Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis;Cell Reports;2024-01

4. Preventing NK cell activation in the damaged liver induced by cabozantinib/PD-1 blockade increases survival in hepatocellular carcinoma models;2023-10-23

5. Prdm1 Positively Regulates Liver Type 1 ILCs Cancer Immune Surveillance and Preserves Functional Heterogeneity;2023-10-23